Direct comparison of bioabsorbable and biodurable polymer everolimus-eluting stent in neointimal stent coverage and in-stent thrombus using high-resolution angioscope

Abstract Background/Introduction Although second-generation drug eluting stent (DES) employing biodurable polymer drastically shortened the duration of dual antiplatelet therapy (DAPT), previous reports raised concerns that switching from DAPT to single increased rates subsequent thrombosis with time. Third-generation DES bioabsorbable has been introduced so as not hinder healing process vessel wall, however, at present, both and those are used in parallel. It means there is no conclusive evidence regarding pros cons these two types polymers. Purpose This study aims clarify how act on human coronary artery by observing neointimal coverage (NIC) in-stent thrombus comparing third-generation bioabsorbable-polymer cobalt-platinum everolimus-eluting (BP CoPt-EES), biodurable-polymer cobalt-chromium (DP CoCr-EES). Methods a multicenter observational including 11 hospitals. We investigated 70 stents CoPt-EES: 40, DP CoCr-EES: 30) 60 cases, who underwent implantation followed simultaneous observation angiography, IVUS angioscopy within 6 12 months. For angioscopy, we recently available, high-resolution angioscope pixel count 9,000 which realized analysis planar detection precisely. Neointimal was graded G0: non G3: full coverage, heterogeneity value neointima measured difference between maximum minimum NIC grade. Results A strong relationship observed grade all (p=0.0011), (p=0.012). There statistical BP CoPt-EES vs. CoCr-EES; 0: 0 (0.0%) 2 (6.7%), 1: 13 (32.5%) (36.7%), 2: (15.0%) (20.0%), 3: 21 (52.5%) p=0.17) neither (p=0.49). The ratio did reach difference; 16 (40.0%) 17 (56.7%) CoCr-EES (p=0.23). Conclusion existence associated coverage. significant EES after months following deployment. FUNDunding Acknowledgement Type funding sources: Private company. Main source(s): Boston Scientific JapanOvalis ltd